Trend of estimated glomerular flitration rate in a large cohort of HIV mother-to -child infected patients, an observational multicenter study from 2010 to 2018

Background: People vertically infected with HIV (PVI-HIV) are a special population, due to exposition since birth to HIV and antiretroviral therapy (ART). Among ART, Tenofovir disoproxil fumarate (TDF) was widely used in recent years, but there are few data on safety in these patients; in particular, data about estimated glomerular filtration rate (eGFR) trend in this population. Aim of our study is to evaluate eGFR trend in a multicentre cohort of PVI-HIV exposed to TDF

Fertigation affects photosynthesis, modulation of secondary metabolism and sensory profiles of Vitis vinifera cv. “Schioppettino” withered grapes and wines

Nowadays a balance in plant production is required, especially in terms of nutrition, yield and for an optimal aroma and sensory profile of resulted wines. In this research, we compared two different methods of plant nutrition: one-single application (single-fertilization-SF) and two applications with the same amount adopting the fertigation (split fertigation-SpF), including a control not-treated, in a specific Italian region where grapevine Schiopettino cv. is being cultivated and this practice was not investigated yet. SpF promoted the photosynthesis parameters compared to a SF and to the non-treated vines (NTC). On these basis, the biological and physiological activity of the whole plant was enhanced. SpF treatment tendentially and significantly improved the qualitative, productive, physiological, and oenological parameters of “Schioppettino” wine

Inter-comparison of Radio-Loudness Criteria for Type 1 AGNs in the XMM-COSMOS Survey

Limited studies have been performed on the radio-loud fraction in X-ray selected type 1 AGN samples. The consistency between various radio-loudness definitions also needs to be checked. We measure the radio-loudness of the 407 type 1 AGNs in the XMM-COSMOS quasar sample using nine criteria from the literature (six defined in the rest-frame and three defined in the observed frame): $R_L=\log(L_{5GHz}/L_B)$, $q_{24}=\log(L_{24\mu m}/L_{1.4GHz})$, $R_{uv}=\log(L_{5GHz}/L_{2500\AA})$, $R_{i}=\log(L_{1.4GHz}/L_i)$, $R_X=\log(\nu L_{\nu}(5GHz)/L_X)$, $P_{5GHz}=\log(P_{5GHz}(W/Hz/Sr))$, $R_{L,obs}=\log(f_{1.4GHz}/f_B)$ (observed frame), $R_{i,obs}=\log(f_{1.4GHz}/f_i)$ (observed frame), and $q_{24, obs}=\log(f_{24\mu m}/f_{1.4GHz})$ (observed frame). Using any single criterion defined in the rest-frame, we find a low radio-loud fraction of $\lesssim 5\%$ in the XMM-COSMOS type 1 AGN sample, except for $R_{uv}$. Requiring that any two criteria agree reduces the radio-loud fraction to $\lesssim 2\%$ for about 3/4 of the cases. The low radio-loud fraction cannot be simply explained by the contribution of the host galaxy luminosity and reddening. The $P_{5GHz}=\log(P_{5GHz}(W/Hz/Sr))$ gives the smallest radio-loud fraction. Two of the three radio-loud fractions from the criteria defined in the observed frame without k-correction ($R_{L,obs}$ and $R_{i,obs}$) are much larger than the radio-loud fractions from other criteria.Comment: 12 pages, 7 figures, MNRAS submitte

Jet-disc coupling through a common energy reservoir in the black hole XTE J1118+480

We interpret the rapid correlated UV/optical/ X-ray variability of XTE J1118+480 as a signature of the coupling between the X-ray corona and a jet emitting synchrotron radiation in the optical band. We propose a scenario in which the jet and the X-ray corona are fed by the same energy reservoir where large amounts of accretion power are stored before being channelled into either the jet or the high energy radiation. This time dependent model reproduces the main features of the rapid multi-wavelength variability of XTE J1118+480. Assuming that the energy is stored in the form of magnetic field, we find that the required values of the model parameters are compatible with both a patchy corona atop a cold accretion disc and a hot thick inner disc geometry. The range of variability timescales for the X-ray emitting plasma are consistent with the dynamical times of an accretion flow between 10 and 100 Schwarzschild radii. On the other hand, the derived range of timescales associated with the dissipation in the jet extends to timescales more than 10 times larger, confirming the suggestion that the generation of a powerful outflow requires large scale coherent poloidal field structures. A strong requirement of the model is that the total jet power should be at least a few times larger than the observed X-ray luminosity. This would be consistent with the overall low radiative efficiency of the source. We present independent arguments showing that the jet probably dominates the energetic output of all accreting black holes in the low-hard state.Comment: 14 pages, 2 figures, to appear in MNRA

A bright megaelectronvolt emission line in γ\gamma-ray burst GRB 221009A

The highly variable and energetic pulsed emission of a long gamma-ray burst (GRB) is thought to originate from local, rapid dissipation of kinetic or magnetic energy within an ultra-relativistic jet launched by a newborn compact object, formed during the collapse of a massive star. The spectra of GRB pulses are best modelled by power-law segments, indicating the dominance of non-thermal radiation processes. Spectral lines in the X-ray and soft $\gamma$-ray regime for the afterglow have been searched for intensively, but never confirmed. No line features ever been identified in the high energy prompt emission. Here we report the discovery of a highly significant ($> 6 \sigma$) narrow emission feature at around $10$ MeV in the brightest ever GRB 221009A. By modelling its profile with a Gaussian, we find a roughly constant width $\sigma \sim 1$ MeV and temporal evolution both in energy ($\sim 12$ MeV to $\sim 6$ MeV) and luminosity ($\sim 10^{50}$ erg/s to $\sim 2 \times 10^{49}$ erg/s) over 80 seconds. We interpret this feature as a blue-shifted annihilation line of relatively cold ($k_\mathrm{B}T\ll m_\mathrm{e}c^2$) electron-positron pairs, which could have formed within the jet region where the brightest pulses of the GRB were produced. A detailed understanding of the conditions that can give rise to such a feature could shed light on the so far poorly understood GRB jet properties and energy dissipation mechanism.Comment: Submitte

A quasar-galaxy mixing diagram: quasar spectral energy distribution shapes in the optical to near-infrared

We define a quasar-galaxy mixing diagram using the slopes of their spectral energy distributions (SEDs) from 1 \u3bcm to 3000 \uc5 and from 1 to 3 \u3bcm in the rest frame. The mixing diagram can easily distinguish among quasar-dominated, galaxy-dominated and reddening-dominated SED shapes. By studying the position of the 413 XMM-selected type 1 AGN in the wide-field `Cosmic Evolution Survey' in the mixing diagram, we find that a combination of the Elvis et al. mean quasar SED with various contributions from galaxy emission and some dust reddening is remarkably effective in describing the SED shape from 0.3 to 3 \u3bcm for large ranges of redshift, luminosity, black hole mass and Eddington ratio of type 1 AGN. In particular, the location in the mixing diagram of the highest luminosity AGN is very close (within 1\u3c3) to that of the Elvis et al. SED template. The mixing diagram can also be used to estimate the host galaxy fraction and reddening in quasar. We also show examples of some outliers which might be AGN in different evolutionary stages compared to the majority of AGN in the quasar-host galaxy co-evolution cycle

Spectral energy distributions of type 1 AGN in XMM-COSMOS – II. Shape evolution

The mid-infrared-to-ultraviolet (0.1–10 μm) spectral energy distribution (SED) shapes of 407 X-ray-selected radio-quiet type 1 active galactic nuclei (AGN) in the wide-field ‘Cosmic Evolution Survey’ (COSMOS) have been studied for signs of evolution. For a sub-sample of 200 radio-quiet quasars with black hole mass estimates and host galaxy corrections, we studied their mean SEDs as a function of a broad range of redshift, bolometric luminosity, black hole mass and Eddington ratio, and compared them with the Elvis et al. (E94) type 1 AGN mean SED. We found that the mean SEDs in each bin are closely similar to each other, showing no statistical significant evidence of dependence on any of the analysed parameters. We also measured the SED dispersion as a function of these four parameters, and found no significant dependences. The dispersion of the XMM-COSMOS SEDs is generally larger than E94 SED dispersion in the ultraviolet, which might be due to the broader ‘window function’ for COSMOS quasars, and their X-ray-based selection

Splenic trauma : WSES classification and guidelines for adult and pediatric patients

Spleen injuries are among the most frequent trauma-related injuries. At present, they are classified according to the anatomy of the injury. The optimal treatment strategy, however, should keep into consideration the hemodynamic status, the anatomic derangement, and the associated injuries. The management of splenic trauma patients aims to restore the homeostasis and the normal physiopathology especially considering the modern tools for bleeding management. Thus, the management of splenic trauma should be ultimately multidisciplinary and based on the physiology of the patient, the anatomy of the injury, and the associated lesions. Lastly, as the management of adults and children must be different, children should always be treated in dedicated pediatric trauma centers. In fact, the vast majority of pediatric patients with blunt splenic trauma can be managed non-operatively. This paper presents the World Society of Emergency Surgery (WSES) classification of splenic trauma and the management guidelines.Peer reviewe

WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections

Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections. Together, the World Society of Emergency Surgery, the Global Alliance for Infections in Surgery, the Surgical Infection Society-Europe, The World Surgical Infection Society, and the American Association for the Surgery of Trauma have jointly completed an international multi-society document to promote global standards of care in SSTIs guiding clinicians by describing reasonable approaches to the management of SSTIs. An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting evidence was shared by an international task force with different clinical backgrounds.Peer reviewe